![]() But the field is still in its infancy and such a small fraction of the human genome is understood that the approach has limited value in its current form. This trend of tailored pharmacology is coming to fruition with products like 23andMe. It's easy to imagine a future where doctors cheaply synthesize a patient's genome to help choose the best drug. Pharmacogenomics is the budding field of medicine that deals with how genes affect a person's response to medications. Genetics play a big role in response to drugs. How Genetics and Metabolism Affect Response to Modafinil Adding modafinil to the mix just unmasks this latent tendency toward anxiety. Some people are already prone to anxiety to begin with. But if you're relatively energetic to begin with, modafinil can push you into overstimulated territory.Īnxiety is like a sliding scale it's not continuous rather than discrete. If you tend to be low-energy, then modafinil is less likely to make you anxious. Baseline Level of ArousalĪ big factor that affects whether modafinil makes you anxious is your baseline state. Whether or not you'll experience anxiety on modafinil depends on many factors, like your baseline level of anxiety, your genotype, and the environment. Modafinil has the opposite effect - it boosts histamine rather than blocking it - increasing wakefulness.īesides histamine, modafinil also decreases GABA and increases glutamate, dopamine, and orexin. If you've ever taken an anti-histamine like Benedryl, you know how drowsy antihistamines can make you. Modafinil stimulates specific circuits in the HPA axis to increase adaptive stress 14. How, mechanistically, does modafinil cause anxiety? The reason that modafinil causes anxiety in some people is straightforward.īut too much of a good thing leads to a state of overstimulation and heightened anxiety. Other studies 13 also suggest a higher incidence of anxiety with modafinil. This suspicion is based on my own experience and anecdotal reports from friends and internet strangers. I suspect that the frequency of anxiety with modafinil is much higher than 7%. In the study referenced in this graphic, 7% of participants on modafinil reported anxiety vs 5% with placebo. So I developed some techniques to better cope with anxiety on modafinil.īefore diving in, let's take a look at modafinil's side effect profile: Overall I benefit from the drug and will continue to buy modafinil from AfinilExpress. Until I learned how to manage it, modafinil made me anxious and once precipitated a full-blown panic attack. There's no question that modafinil can cause anxiety. It gets quite intense with modalert that it's nearly unbearable at times. When I'm anxious it's always been a nervous "butterfly" tingly type feeling in my chest (rather than the stomach, which I don't think I've ever felt). ![]() I find that a few hours after having some, my anxiety levels shoot up. I've been experimenting with dosage of Modalert for the past week (currently at around 100mg a day but I will decrease). Any of you'll had experience like this before? Any advice is appreciated. Right now this feeling is really shitty, I only feel like smoking cigarettes. However today I got up late around 1pm and took one 200mg(last dose was 4 days ago) This is the first time I'm experiencing an anxiety attack after taking modalert, I tried calming myself down tried meditating but it keeps coming back. I take a dosage of 200mg twice in a week right after I wake up around 9am and start working at my home office. Hey, I've been taking Modalert since 2 months now. Look online and you'll find countless reports 1 2 of modafinil causing anxiety: Also, please chime in if you have personal experience with modafinil and anxiety. If you're most interested in tips to reduce anxiety on modafinil, skip down to the section Coping With Modafnil-Induced Anxiety.
0 Comments
Leave a Reply. |